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Hollywood makes a lot of movies dealing with a lot of different things Hollywood has done several movies dealing with the medical field One of them is Lorenzos Oil that talks about adrenoleukodystropy Another is The Awakenings which talks about encephalities lethargica Adrenoleukodystrophy ALD is an X-linked genetic disorder This means that only girls have the gene for the ALD and they pass it on to all their children but it only affects the boys but girls are carriers so they could pass it on to their kids Narins In the movie Lorenzos Oil Lorenzo has the child form of ALD which is also the most familiar and severe form It normally arises between the ages of four to ten An ALD patient may lose sight and hearing They will have learning disabilities seizures poor verbal communication problems consuming food weariness and nausea What is Adrenoleukodystrophy Lorenzos Oil is usually used to treat ALD in children It lowers the amounts of very-long-chain-saturated-fatty acids VLCSFA In theory this delays demyelination from occurring The only crook in this treatment is that it cannot cross the blood-brain barrier so it has no effect on the VLCSFA levels in the brain Radley ALD is a genetic disorder distinguished by demyelination of nerves in the brain andor the spinal cord Demyelination is a process in which myelin breaks down Demyelination occurs because the body cannot break down very-long-chain-saturated-fatty acids VLCSFAs The buildup of VLCSFA causes the nerve to short-circuit or not function like normal Radley The buildup occurs in the brain and adrenal cortex Adrenoleukodystrophy VLCSFA refers to fatty acids that are 24 or 26 carbons long The saturation part of VLCSFA refers to the fact that the carbons in the chain are saturated with hydrogens In ALD the VLCSFAs build up in the blood stream up to two to four times higher in ALD patients than the average person Saturated fatty acids are straight and
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