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I will be addressing the possible immunological barriers that may be involved with challengeto infection of Toxoplasmosa gondii the protozoan that causes toxoplasmosis It is widely knownthat toxoplasmosis is a devastating disease with often drastic consequences upon infection Inpregnant mothers these consequences can be very horrid Such effects are more felt by the unbornfetus than by the mother These effects include abortion premature birth and severe growthretardation Creasy et al 1994 Falkner et al have shown that the human fetus is capable of producing antibodies as early as ten weeks gestation time We also know that antibodies totoxoplasmosis exist which are of Ig G Ig M and recently demonstrated although in low levels IgThese facts give rise to some questions regarding the bizarre reactions of the fetus whichshould be more than protected enough from infection Why is the fetus damaged or even abortedfrom such a challenge when it has the ability to produce antibodies Are any of the antibodiesproduced specific for toxoplasmosis Are the maternal antibodies that may exist to toxoplasmosisfound in fetal serum due to the passive immunity from mother to child or are they blocked bysome selection mechanism in the placenta My objectives are to find out 1if the placenta does in fact serve as an antibody spongeCreasy et al 2if the fetus produces antibodies specific for toxoplasmosis 3if fetal antibodiesspecific for toxoplasmosis are found what isotype they are to determine if they might be of maternalorigin since Ig G readily crosses the placenta 4if the antibodies found have a high affinity fortoxoplasmosis immunogen and are capable of eliciting an effective immune responseI will be addressing the fetal response to challenge with toxoplasmosis infection We doknow that there is immune response activity in the fetus at the age of four months gestation thusthey are capable of producing antibodies along with the ones that they receive via the placenta inpassive immunity We also know that there are antibodies specific for toxoplasmosis Lastly weknow that
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