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Alzheimers disease Neurobiology causes and treatments of Alzheimers Disease AD is one of the most common of the dementing illnesses A progressive degenerative disease that attacks the brain causing impaired memory thinking and behavior A person with Alzhiemers Disease may experience personality and behavior changes impaired judgment confusion and difficulty finishing thoughts following directions or even finding the right word to say in a conversation Once advanced the sufferer may require a caretaker as daily chores become very difficult to accomplish Evidence points toward amyloid as one of the main causes for the occurring cytotoxic processes Researchers have found that degeneration appears to be caused by interference with intracellular calcium homeostasis via activation of calcium channels intracellular calcium stores and further production of free radicals by calcium-sensitive enzymes The glutamatergic system seems to be involved in mediating the toxic processes In the brain the nerve cells in the part that controls memory and thinking are damaged this interrupts the passage of messages between communicating cells The cells undergo distinctive changes these are called neuritic plaques groups of degenerating nerve cell ends and neurofibrillary tangles groups of twisted filaments which accumulate in previously healthy nerve cells The cortex used for thinking of the brain shrinks the spaces in the center of the brain become enlarged causing reduction of the surface area in the brain Symptoms of AD usually occur in older adults and are the ones most at risk although people in their 40s and 5Os may also be affected The symptoms include a loss of intellectual capacity loss of language skills which may include having trouble finding words poor or decreased judgment problems with abstract thinking disorientation in place and time changes in mood or behavior and changes in personality AD does not discriminate it affects any race socio background or sex equally The classic symptom of forgetfulness is part of the normal aging
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