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KLINEFELTERS SYNDROME Klinefelters syndrome is a genetic disorder that is only found in males Until recently you could not detect this disorder until after puberty but now they can detect it before birth using amniocentesis Amniocentesis is the use of a long needle to withdraw amniotic fluid surrounding the fetus Klinefelters syndrome was first discovered by HF Klinefelter in 1942 This disease affects about one in one thousand males that are born Klinefelters syndrome is caused by an extra X chromosome which is caused by an error in meiosis to make a combination of XXY also known as a trisomal karyotype Although the extra X chromosome is inactive also known as a Barr body it still interferes with the development of some male characteristics Other causes of this disease are excessive alcohol intake hormone disturbance and urinary tract infections Some STDs such as syphilis and non specific urethritis can cause a male to get this disease also The older a woman is when she gives birth to her child the more likely the son is to have Klinefelters syndrome Even so it is not a hereditary disease Along with the interference of the development of male characteristics Klinefelters can cause someone to have some mental retardation the condition does not worsen nor does it get better after birth As the number of X chromosomes increase the severity of mental retardation and malformation will also increase Some other effects of this disease are the plasma concentration of the male hormone testosterone is often low and they are unable to impregnate a female in other words they are sterile Someone with Klinefelters syndrome often has trouble learning to read and write this will often times cause them to speak later than others Klinefelters syndrome can cause problems with a males genitals and his endocrine system Some physical effects of this disease are that a person tends to be taller have longer limbs and their testes
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