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IntroductionMuch of drug discoveries nowadays are established on the concept of choosing specific targets of bioactive macromolecules by small molecular mass drugs Moreover the paramount of the pharmacological activity is the binding of the selected drugs to their targets Robert et al 2007 In the past specifically around the twentieth century Paul Ehrlich expressed a phrase that became an important subject of discussion in modern pharmacology and molecular medicine corpora non-agunt nisi fixate which means a substance will not work unless it is boundEhrlich 1913 In this assignment I will discuss weather this statements is true or may elicits its own exceptionsDiscussion Proteins lipid DNA and receptors are all examples for important cell and tissues constituents whom many drug bind to it in order to perform a therapeutic effect However scientists discover that there are some drugs that offer an effect without binding to such cell or tissue constituents as antacids osmotic diuresis osmotic purgatives and heavy metals Nevertheless the principle remains true for the majority of drugs that they will not develop an effect unless they are boundMost drugs acts through receptors which are cellular macromolecule that have a major concern in directing chemical signals between and within cells Neubig 2003 Indeed a combination of a hormone neurotransmitter drug or intracellular messenger with its receptor produces a change in the cell function Those changes might evoke stimulatory or inhibitory effect therefore we call the drug as an agonist On the other hand when the drug binds to its target and cause no particular function or a blocking effect it is called an antagonist Furthermore receptors must have certain characteristics to achieve their full potentials as having suitable features to permit their specificity and sensitivity In addition for their active biological binding sites The binding and the activation process are governed by two phenomena affinity and efficacy While the drug may have an affinity to bind to a receptor it may or may
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