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Addictive disorders have been studied from genetic perspective for morethan ten years Before they were believed to be associated withindividuals personality weakness Endophenotype is a concept that helpsto investigate genetic impact on psychiatric disorders like addictionThe perspective is linking genes and the phenotype of particularpsychiatric disorder on neurobiological neuroanatomical orneuropsychological level Endophenotype must be heritable and beassociated with certain disorder also it must represented in higherrate in unaffected family members These characteristics makeendophenotype closer to genetic basis than the disorder itself hencebeing perfect candidate for several genetic and imaging studies Thisessay addresses the following question Why is the endophenotypeapproach suitable for genetic studies of addictive disorders What areits limitations At the outset of the essay the concept of endophenotype is presentedAddictive disorders and their endophenotypes linking genetics andbehavioural traits of addiction follows The last section argues thatthere is only one model of endophenotype possible and as such is usefulfor addiction studies Finally the conclusion very briefly summarisesthe main points of the paper EndophenotypeThe term endophenotype has been recently employed because the usedapproaches did not bring much success into linking geneticpredispositions to psychiatric disorders ADDIN CSLCITATION citationItems id ITEM-1 itemData DOI 101038sjmp4002068 ISSN 1359-4184 PMID 17895920author dropping-particle family Walters given J T R non-dropping-particle parse-names false suffix dropping-particle family Owen given M Jnon-dropping-particle parse-names false suffix container-title Molecular psychiatry id ITEM-1 issue 10 issued date-parts 2007 10 page 886-90 title Endophenotypes in psychiatric genetics type article-journal volume 12 uris httpwwwmendeleycomdocumentsuuid112d722f-7b2b-4908-88b8-f2b63f64062a mendeley previouslyFormattedCitation Waltersand Owen 2007 properties noteIndex 0 schema httpsgithubcomcitation-style-languageschemarawmastercsl-citationjson Walters and Owen 2007 Psychiatric disorders diagnosesare solely based on subjective symptoms therefore the search for theiraetiological vindication
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