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Word Count: 462
MDA 34-methylenedioxyamphetamine The following synthesis is not meant to be carried out by a novice chemist although it is not terribly difficult For descriptions of how to carry out the procedures a standard lab procedures reference manual should be aquired by the reader or preferably the reader should take college organic chemistry This is the synthesis for MDA which can be found on page 79 of Psychedelic Chemistry which was first published in Chemical Abstracts 52 11965c 1958 The former however has the above noted typographical error of 75 ml 15 HCl being written as 57ml 15 HCl The original article also has a typographical error In the synthesis of MDA from the ketone it reads H2O2 where it should read H2O -- following the former procedure would be explosive As a side note this is the same process of making the ketone from isosafrole as Shulgin uses in PiHKAL thus the synthesis of the ketone is somewhat more verbose than the synthesis of MDA from the ketone To a well stirred cooled mixture of 34g of 30 H202 hydrogen peroxide in 150g 80 HCO2H formic acid there was added dropwise a solution of 324g isosafrole in 120ml acetone at a rate that kept the reaction mixture from exceeding 40 deg C This required a bit over 1 hour and external cooling was used as necessary Stirring was continued for 16 hours and care was taken that the slow exothermic reaction did not cause excess heating An external bath with running water worked well During this time the solution progressed from an orange color to a deep red All volatile components were removed under vacuum which yielded some 60g of a very deep residue This was dissolved in 60ml of MeOH methyl alcohol -- methanol treated with 360ml of 15 H2SO4 sulfuric acid and heated for 3 hours on the steam bath After cooling the mixture was extracted with 3x75ml Et2O diethyl ether
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