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Word Count: 1,139
Hemophilia is the best known of hemorrhagic disorders When a person has hemophilia the blood does not clot properly and bleeding persists The people who have hemophilia are called hemophiliacs or bleeders Bleeding disorders such as hemophilia result from a disruption of the bodys process of how blood clots are formed The coagulation process involve platelets as well as plasma proteins called clotting factors Clotting begins when platelets stick to the site of an injury to a blood vessel The proteins in the plasma that cause blood to clot is absent Hemophilia is named from a Greek word meaning fond of blood There are two types of hemophilia Hemophilia A which is the most common and is also called classic hemophilia Hemophilia B or Christmas disease named after the first patient diagnosed and treated with hemophilia B Hemophilia B lacks AHF antihemophilic factor About 85 of hemophiliacs have classic or hemophilia A Hemophilia As blood lacks the clotting factor eight The rest of the 85 have Christmas which lacks clotting factor nine An extremely small number of hemophiliacs lack yet another kind of clotting factor Both A and B forms have also been called the royal disease Hemophilia was inherited by decedents of Englands Queen Victoria and introduced into the royal houses of Spain Germany and Russia Hemophilia A and B are caused by genes that are sex linked and recessive A defective gene on the X chromosome one of the two chromosomes that determine a persons sex The Y chromosomes which has no genes for clotting is the other chromosome Males have one X chromosome and one Y chromosome Girls have two X chromosomes A boy who inherits the hemophilia defect on his X chromosome will most defiantly will be a hemophiliac A girl who inherits the defective gene on her X chromosome will be a carrier instead of hemophiliac because the normal gene on her X chromosome
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