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Alzheimers Disease is a disorder involving deterioration in mental functions resulting from changes in brain tissue This changes include shrinking of brain tissues not caused by disorders of the blood vessels wwwyahoocom 2000 This disorder is also known as primary generative dementia diffuse brain atrophy and senile dementia Senile dementia Alzheimers type SDAT is the most common cause of intellectual decline with aging The incidence is approximately nine out of ten thousand people and it affects women more often than men occurring primarily in older people The cause is unknown but several factors are believed to be involved in the development of the disorder although none have yet been proven The neurochemical factors include lack of substances used by the nerve cells to transmit nerotransmitters including acetylcholine somatostatin and norepinephrine Environmental factors include exposure to aluminum manganese and other substances The infectious factors include virus like organisms called prion infections that affect the central nervous system In some families representing 5 to 10 of cases there is an inherited predisposition to development of the disorder but this does not follow strict patterns of inheritance In able to make a diagnosis other causes of dementia must be ruled out The procedures vary but usually neuromuscular examinations psychological tests and physiological exams such as CT scan and electroencephalogram are made Researchers have found that in families that have multiple members with Alzheimers there is a particular gene variation which is common to all of those with the disease The gene which produces a substance called apolipoprotein E4 is not said to cause the disease but its presence increases the chances that the disease may eventually occur There are many people who have the E4 gene and never become afflicted with Alzheimers The onset of the disorder in a person is characterized by impaired memory with progressive loss of intellectual function There might appear mood changes changes in language capability changes in way of walking and other
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