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The product being tested is a salamol CFC-free Easi-Breathe inhaler Each actuation of the inhaler delivers Salbutamol Sulphate Ph Eur equivalent to Salbutamol 100 micrograms into the mouthpiece of the adapter Salbutamol is a selective 9462-adrenoceptor agonist At therapeutic doses it acts on the 9462-adrenoceptors of bronchial smooth muscle providing short acting 4-6 hour bronchodilatation with a fast onset within 5 minutes in reversible airways obstruction Salamol is indicated in the management of bronchial asthma for the relief of wheezing and shortness of breath used on an as required basis The inhaler may be used as necessary to relieve attacks of acute dyspnoea and may be used prophylactically before exertion or to prevent exercise-induced asthma The inhaler may also be used in the treatment of the reversible component of airways obstruction The metered dose inhaler MDI being is used in this experiment is the salamol inhaler as previously mentioned It is a relatively new inhaler on the british market The contents of the MDI are Norflurane HFA 134a Ethanol anhydrous and Salbutamol Sulphate The inhaler contains a new propellant and does not contain chlorofluorocarbons CFCs In the past the main propellants used in inhalers were all CFC based which had a detrimental effect on the Ozone layer Due to the International Legislation of the Montreal Protocol an international agreement on targets for the elimination of CFCs and HCFCs signed by 58 countries in 1990 the pharmaceutical industry are currently exempted from this ban on CFCs but this exemption is reviewed annually This has forced the pharmaceutical industry to seek more ozone friendly propellants The norflurane HFA 134a acts as the propellant in the easi-breathe which is a hydroflurocarbon HFA and is Ozone friendly The drug substance is dispersed in the propellant upon spraying the propellant and the drug are dispersed and the head volume in the counter increases As a result the propellant evaporates in order to restore the
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