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Hemophilia Manitoba Hemophilia Manitoba or hemophilia is a sex-linked genetic disorder that is effecting about 20000 Americans most of which males A person with hemophilia either has an inactive or inadequate supply of one of several blood factors needed for blood to clot Because of this hemophilia can be mild moderate or severe Severe hemophiliacs are at risk for bleeding during surgery trauma or even dental work There are two types of hemophilia A and B Christmas disease Hemophilia B is extremely rare The majority of the people have hemophilia A In hemophilia A the particular factor missing is 8 for clotting Because hemophilia is sex-linked disorder it can be passed on from mother to child This is because the gene responsible for making blood factors 8 and 9 are only found on the X-chromosome If a female is a carrier that means that she has one bad gene and one good gene for this disease There is a fifty percent chance that she would pass it on to her child because she can only pass on one of the two chromosomes If a male has hemophilia he will have normal sons and all of his daughters will be carriers of the hemophilia disorder because all he can pass on is the defective X-chromosome Males mostly have hemophilia but women can also have hemophilia This is extremely rare though because two defective X-chromosomes would be needed In fact the first proven case of women having hemophilia was not until the 1950s Bornstein 89 Female carriers are also at risk These women are known as asymptomatic carriers and may suffer excessive menstrual bleeding bruising nosebleeds and problems during childbirth One serious problem with hemophilia is joint bleeds When a joint bleeds a small
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