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The effect of Vitamin D supplementation on patients with secondary hyperparathyroidism and hemodialysis helps the parathyroid hormone return to its normal set point The effect of intravenous 1 25OH2D therapy has been shown to increase the parathyroid hormone PTH secretion 1 The subjects for this experiment were fourteen normal people and 13 patients with undergoing hemodialysis The hemodialysis patients were then broken down into 6 patients with elevated PTH EBI at greater than 10 pmolL and seven patients with near normal PTH NNBI at less than 10 pmolL The normal patients parathyroid function was measured at two hour intravenous infusions of CaCl2 and Na2EDTA on two different mornings three days apart and while fasting The blood was obtained during the basal state and every fifteen minutes during infusion In the hemodialysis patients the calcium was modulated by increasing the calcium dialysate concentration and then one week later decreasing the calcium dialysate concentrations The blood samples were taken before dialysis and fifteen minutes after during two hours Second evaluation of the parathyroid came after the patients received intravenously 1 ug of vitamin D Ionized calcium phosphate and 125OH2D were also measured In NNBI patients the basal PTH was 63- 25 pmolL and after the 1 month of intravenous came down to near normal ranges at 30-18 The EBI patients had a very high basal PTH at 492- 395 and then after 1 month came down to 300 - 324 Patients with the severe hyperparathyroidism were hypocalcemic at 116- 005NNBI and 110 -003 and then after increased to 125 - 07 and 116-03 respectively Also increased phosphate and 125OH2D This may implicate that if either there is a lower calcium level or and increase in phosphate levels this may stimulate the parathyroid Finally the set point in both NNBI 109-116 and EBI 108- 112 patients increased to closer to normal values 118 - 04 Intravenous 125OH2D did help patients set point return
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