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ATP Production Metabolism which encompasses glycolysis the Krebs cycle and the electron transport system occurs in the mitochondria of cells The mitochondria consist of a double membrane and an inner compartmentalization called the matrix Each of the processes of metabolism occurs in specific locations in and around the mitochondria The process of glycolysis occurs in the cytoplasm just outside the outer membrane of the mitochondria The Krebs cycle occurs within the matrix and the electron transport system in the convoluted inner membrane called the cristae When considering the location and process of the electron transport system you would observe that all of the components enzymesproteins necessary for this process are contained with the cristae membrane When trying to define a starting point concerning the production of ATP you could consider glycolysis Glycolysis basically provides the components which will ultimately drive the process involved in ATP production Glycolysis yields two three-carbon compounds called pyruvate from one glucose molecule Pyruvate plays a crucial role in the Krebs cycle Glycolysis also yields a number of Hydrogen ions and electrons which will be used in the electron transport system Glycolysis also yields a net production of two ATP Before the pyruvate molecules can be used in the Kreb cycle they must be converted to Acetyl CoEnzyme A Acetyl CoA This occurs during the intermediate step CoEnzyme A is introduced to the two pyruvate molecules from glycolysis An NAD picks up a hydrogen ion from both the CoEnzyme A and the pyruvate CoEnzyme A reacts with the pyruvate releasing carbon dioxide and yields Acetyl CoA Acetyl CoA will now enter the Krebs cycle within the matrix Acetyl CoA starts the Krebs cycle by catalyzing a reaction between the Acetyl portion of Acetyl CoA and oxaloacetate This yields a six-carbon compound called citrate or citric acid Next a water molecule is released from the citrate causing a change in the structure The water is then added back on to
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