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DISEASE Cystic fibrosis is an autosomal recessive trait on chromosome 7 This disorder affects chloride transport resulting in abnormal mucus production This lifelong illness usually gets more severe with age and can affect both males and females Symptoms and severity differ from person to person Cystic fibrosis is the most common fatal inherited disease among whites and the major cause of chronic lung disease in children 50 of people are expected to live to be 30 but a majority die before age thirteen 12000 whites have cystic fibrosis 117000 blacks 16000 live births 12500 Americans and 120 is a carrier The genes are inherited in pairs with one gene coming from each parent to make the pair Cystic fibrosis occurs when both genes have mutations A person with cystic fibrosis receives one cystic fibrosis gene from each parent The parents of a child with cystic fibrosis each carry one nonworking copy of the gene and one working copy of the gene The parents are called cystic fibrosis carriers and because they have one working gene they have no symptoms Carrier parents have 14 chance to have a child who is a noncarrier of cystic fibrosis a 12 chance to have a child who carries the gene and a 14 chance with each pregnancy to have an affected child If you have a son or daughter with cystic fibrosis then you have a 11 chance of being a carrier If you have a brother or sister with CF you have a 23 chance of being a carrier If you have a niece or nephew with CF you have a 12 chance of being a carrier If you have an aunt or uncle with CF you have a 13 chance of being a carrier and a 14 chance if you have a 1st cousin with CF Cystic fibrosis affects the lungs in particular The secretions are thick
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