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Using recombinant DNA technology to make Human haemoglobinA Haemoglobin AHb found in adult humans is essential for their survival as it carries oxygen aroundthe body in the bloodstream Because of the extremely low percentage of blood donors dueto an apathetic view towards this need and the high risks of infected or non-compatibleblood due to diseases and different blood types scientist have been working on a way inwhich they can produce Hb in transgenic tobacco plants Scientists havediscovered the genetic coding of the Hb genes in humans which have coding for theproduction of the necessary polypeptides The gene coding is obtained and inserted intothe plasmids of the bacteria Agrobacterium Tumefaciens The bacterium causes crown galldisease in the Tobacco plant causing the plant to synthesise haemoglobin in theirchloroplasts The production ofHb in the chloroplasts tobacco plants has been found to be very reliable matching Hbproduced by a human This application will bring the result of higher survivalchances for humans It has also been found that the haemoglobin can increase the plantgrowth One major concern is the usefulness of this product Is it really better thandonated blood The general publics acceptance is unknown but it is thought that mostwould be against the idea of a product of tobacco being injected into their bloodstream Relevant Geneticsin Haemoglobin A Synthesis All human cellscontain chromosomes which contain information for the structure and function of humansOn them are found Deoxyribonucleic acid DNA which is a type of nucleic acid on whichgenetic information is held DNA consists of two parallel polynucleotide chains and is inthe form of a double helix whereas Ribonucleic acid RNA is single stranded If DNA isconsidered to be shaped like a ladder the sides are made of sugar-phosphate chainsLinking the chains the rungs are the bases There are four of these AdenineAGuanineG CytosineC and ThymineT Adenine always pairs with Thymine and Cytosinewith Guanine in what are known as base
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