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The factual cause of Parkinsons is unknown Parkinsons Disease is a a progressive disorder characterized primarily by uncontrollable tremors in the limbs a shuffling gait and generalized muscular rigidity It is usually not fatal but leads to changes in the entire body Parkinsons is also know as PD Recently a defective gene found in few families with backrounds of PD was found Though researchers do not believe that genetic conditions are responsible for the disease They instead think that it could be the combination of a genetic preference and an unidentified environmental stimulate When PD occurs degenerative changes are found in an area of the brain which produces dopamine Parkinsons is characterized by a severe shortage of dopamine Over one-and-a-half million Americans are affected by Parkinsons Disease The standard prevalence for PD have been estimated at 120-180 per 100000 in Caucasian populations and the prevalence of the disease in people over 65 years of age is approximately 1 Incidence rates have been estimated at 20 per 100000 Parkinsons Disease ordinarily occurs in elderly individuals Most symptoms are first experienced between the ages of 50 and 60 years of age and onset before 25 is very uncommon Men are affected slightly more often then women although the difference between the two are small There is no nationality that has been found to be immune to the disease or completely devoid of the disease The highest prevalence of Parkinsons Disease is in North America and in Europe and the lowest prevalence rates have been found in China Japan Nigeria and Sardinia The dominant symptoms of Parkinsons Disease are due to abnormalities in the extrapyramidal motor circuit The basal ganglia are subcortical nuclei involving three ingredients which are the caudate nucleus the putamen and the globus pallidus The caudate nucleus includes a head which lies next to the lateral ventricle The body lies next to the lateral which goes to the thalamus and the tail which enters
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