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Chse 235 Efosa Asemota Drug report 2 Cytotec Misoprosto Therapeutic category Mucosal Protective gent Use indicator For the treatment and prevention of NSAID-induced gastroduodenal ulcers Also indicated for the treatment of duodenal ulcers caused by Peptic Ulcer Disease PUD Adverse reaction The most frequent gastrointestinal adverse events were diarrhea 107 abdominal pain 73 nausea 42 flatulence 33 and dyspepsia 32 The incidence of diarrhea was 78 when the total daily dose was 400 In patients receiving placebo the incidence of diarrhea was 36 The events were usually transient and mild to moderate in severity Contraindicationoverdose Possible clinical signs that may indicate an overdose may include sedation tremor fever convulsions dyspnea abdominal pain diarrhea palpitations hypotension or bradycardia Treatment should be symptomatic and supportive Children Safety and effectiveness in patients below the age of 18 have not been established Known sensitivity to prostaglandins prostaglandin analogues or excipients microcrystalline and hydroxypropyl methylcellulose sodium starch glycolate and hydrogenated castor oil Contraindicated in pregnancy Initial dosage The recommended adult oral dosage for the prevention and treatment of NSAID-induced gastroduodenal ulcer is 400 to 800 a day in divided doses NSAIDs should be taken according to the schedule prescribed by the physician When appropriate misoprostol and NSAIDs are to be taken simultaneously Misoprostol should be taken after food Referencewwwdrugscom wwwpharmclipscom httpwwwrxmedcomhttpwwwrxmedcombmainb2pharmaceuticalb2prescribehtml
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