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Degenerative joint disease and limb deformities cause lameness in adolescent pigs Dyschondroplasias osteochondroses typified by failure of endochondral ossification are important predisposing factors for physeal and joint lesions The youngest age when lesions develop the primary cartilage defect pathogenesis of lesions and causes are not established The purpose of the present study was to determine the age of onset and pathogensis of dyschondroplasias in pigs Ninety-two pigs between 1 and 169 days of age were killed and dissected for angiomicrographic radiologic histologic and histochemical investigation Physeal and articular epiphyseal A-E complexes were collected from ribs ischial tuberosities and extremities of long bones Microscopic examination of tissue sections stained with hematoxylin and eosin was the definitive technique for detection of lesions Histochemistry included the demonstration of cartilage proteoglycans mineral radicals and collagen Lesions were in 12 of 21 pigs at 1 day of age and consisted of foci of persistent hypertrophied chondrocytes and matrix in physes or A-E complexes In angiomicrographs vessels frequently crossed normal physes and in abnormal physes vasculature was normal in the vicinity of lesions Chondrocytes in sections of normal growth cartilages prepared for histochemistry were of 2 or more types Heterogeneity among chondrocytes and matrices in the simplest lesions was similar to that in normal physes and A-E complexes Some lesions contained mineralized matrix However areas of chondrolysis which contained little if any proteoglycan or mineral were more typical of a second type of dyschondroplasia in A-E complexes of pigs older than 80 days A secondary center of ossification was in ischial tuberosites of some pigs by 26 days of age Simple lesions existed at 1 day most probably they were congenital Since the prevalence of lesions was relatively high in pigs up to 6 months dyschondroplasias may be part of the usual growth pattern Chondrolytic lesions associated with A-E complexes in older pigs were a different dyschondroplasia Histochemical morphologic heterogeneity among chondrocytes was interpreted as functional heterogeneity related to proteoglycan production
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