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In this review many of the studies deals with the preparation of LDHs with divalent and trivalent in the brucite-like layers containing intercalated drug via three methods and characterization of these samples by different phisicochemical techniques for an advanced drug delivery systems the experimental procedures that used to intercalated drugs and the comparison between them have been reported by some authors More research effort were focused on the effect of the intercalation on the drug release rate which were studied under different conditions or the amount of drug released and on the stability of the organic drug molecules Additionally its effect on the solubility and dissolution rate of the drug anionsAs there are studies discussed the dependence of the cellular uptake of organic molecules and the release of drug from the drugLDHs nanohybrids on different factors example composition charge density surface properties of LDHs and pH value etc besides they reported the effect of the presence of the sodium salts in reaction medium on the drug release process and also addressed the kinetics data of drug release from the nanocomposites Some authors concentrated on the study of the following points i the thermal evolution of the structure of LDH ii the arrangement orientation and geometry of the intercalated drug molecules iii the safety of LDH for cells and iv the antibacterial activity and the anticancer efficacy of drug-LDH systems It should be noted that more than a study were conducted to assess the potential use of polymers as a support for a controlled release formulation of drugs and in order to investigate the physical and mechanical properties of LDHdrugpolymer nanocompositesThe following are some literature examples 2001-2013 on the interaction of 7 families of pharmaceutically active compounds with layered double hydroxides LDHs these families can be classified as follows antibiotic drugs eg gramicidin amphotericin
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