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Tendinopathy is a painful condition that occurs in the tendons and can be referred to as Achilles tendon or tendon rupture Studies have show tendon rupture as a class effect of Fluoroquinolones which are a class of antibiotics commonly used for treatment of respiratory and urinary tract infections The use of these antibiotics has increased during the past decades in most countries Two studies Impact of age sex obesity and steroid use on quinolone-associated tendon disorders and Evidence of tendinitis provoked fluoroquinolone treatment both concluded Fluoroquinolone being a class effect of tendon rupture Achilles rupture and tendon disorders as a whole Both large population based studies show excellent evidence of fluoroquinolone-induced tendinopathySTUDY 1Wise et al performed a retrospective cohort case crossover study on the general population of the United Kingdom The primary outcome was Achilles tendonitis since it has been acknowledged in the past with known association with quinolone use The secondary outcome was tendon rupture because it was thought that other classifications of tendinopathy such as tendonitis were subject to greater misclassification bias The study was based on information derived from THIN database The database computerized medical information of 64 million residents in the UK that were entered by general practitioners from 1986-2009 Exlusions of this study were subjects whose Achilles tendonitis or tendon rupture was diagnosed within the first 2 years of entry into theTHIN database This was to avoid using diagnoses that might have been entered at the beginning of the subjects participation in the study but that actually represented events that occurred before study entry For each participant they defined a case period as the 30 days immediately before the diagnosis date and a control period as the 30 days 1 year before the diagnosis date It was made sure whether or not the participants had a prescription for a quinolone during this period The inclusion area of interest consisted of age 60 vs 60 sex BMI or 30 vs
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