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Old essay lots o content just needs a good proofread - HUNTINGTONS DISEASE Huntingtons disease also known as Huntingtons chorea is a genetic disorder that usually shows up in someone in their thirties and forties destroys the mind and body and leads to insanity and death within ten to twenty years The disease works by degenerating the ganglia a pair of nerve clusters deep in the brain that controls movement thought perception and memory and cortex by using energy incorrectly The brain will starve the neurons brain cells and sometimes make them work harder than usual causing extreme mental stress The result is jerky random uncontrollable rapid movement such as grimacing of the face flailing of arms and legs and other such movement This is known as chorea Huntingtons chorea is hereditary and is caused by a recently discovered abnormal gene IT15 IT stands for interesting transcript because of the fact that researchers have no idea what the gene does in the body Huntingtons disease is an inherited mutation that produces extra copies of a gene sequence IT15 on the short arm of chromosome 4 A genetic base that exists in triplicate CAG for short is effected by Huntingtons disease In normal people the gene has eleven to thirty-four of these but in a victim of Huntingtons disease the gene exists from anywhere between thirty-five to one-hundred or more The gene for the disease is dominant giving children of victims of Huntingtons disease a 50 chance of obtaining the disease Several other symptoms of the disease exist other than chorea High levels of lactic acid have been detected in patients of Huntingtons disease as a bi-product of the brain cells working too hard Also up to six times above the normal level of an important brain brain protein bFGF or basic fibroblast growth factor in areas of the brain effected by the chorea This occurs from the problems on chromosome 4
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